MUCOSA - GENITALS

The report has been written as to a class of Grade 12 students.

To take them back to the basics it is necessary to start with

embryology – study of the development of the embryo as part

of understanding of HIV infection.

A student in earlier times, I found embryology a difficult study.

There seemed to be such complexity in formation of the embryo.

We all know that there is a sequence in building a house. The

foundation goes in then the superstructure followed by the roof.

We do not hang the curtains till the windows go in. Walls come

before the locked door.

Formation of an embryo would have a million steps governed by

the sequences of DNA. What goes in first, the vertebrae or the

legs and arms? Does the digestive system or the brain form first?

The fact is there are hundreds of concurrent steps. – a designer’s

dream/nightmare. But the embryo is in good hands of the Creator

aka Nature.

What has all this to do with HIV/AIDS? In the early embryo,

the gender is not laid down for several weeks. Then bells start

ringing. It’s a boy. It’s a girl.

Up to this time, genitals have formed in a very basic piece of

flesh hanging outside. If a boy, the flesh forms into a penis. If

a girl, the flesh pulls back into the body like someone peeling

a glove inside out. In physiological terms, it invaginates.

The penis is part of the lymph system in that there are mucosa

and langerhans cells in the inside foreskin. These are present in

the basic piece of flesh that inverts to form the vagina.

If the mucosa cells are inside the foreskin of the boy, these form

the back of the vagina once the invagination is complete. It seems

to be that the basic head of the penis may form part of the cervix

that is laden with mucosa cells.

We are advised that there are mucosa cells in the urinary tract of

the man. It has to be the same in the woman.

Bodies of each living creature are awe-inspiring. Eagles, hump-back

whales, lizards, cockroaches and HIV virus are wonders of design.

Embryonic development has the same basic flow in many. HIV is

just a package of DNA, a wonder in itself.

The mucosal guards (see the report below) are posted where there is

the most danger of infection. That is mouth, anus, penis, vagina and
gut lining.

It is also inside the foreskin of the man and on and beside the cervix

of the woman where semen will be deposited by a penile thrust.

A man can be protected with a proper medical circumcision. It shuts

Door 1 for HIV infection. Door 2 can still be left open by infections

on the penis such as rashes, cuts, sores and genital herpes.

Circumcision Decreases Risk of HIV But Not Other STIs

26 Jan 2005 ... It thus appears that "the preputial mucosa

is an important target ... "Circumcision seems to be almost

uniquely protective against HIV ...
www.urotoday.com/.../3276-circumcision-decreases-risk-

of-hiv-but-not-other-stis-1630.html?... - Cached

Immunity - Immunobiology of Mucosal HIV Infection and the Basis ...

The gastrointestinal and vaginal mucosa are the major routes

of natural HIV transmission, with the former being the primary

reservoir for virus replication. ...
www.cell.com/immunity/abstract/S1074-7613(04)00053-6

- Cached - Similar

Note: Gastrointestinal means the gut lining.

HIV-1 infection of Langerhans cells in a reconstructed vaginal ...

by P Sivard - 2004 - Cited by 16 - Related articles
7 Oct 2010 ... HIV-1 infection of Langerhans cells in a

reconstructed vaginal mucosa. (PMID:15216455). Abstract.

Find all citations by this author ...
ukpmc.ac.uk/abstract/MED/15216455

A woman can not be circumcised.